ORMDL3 expression in ASM regulates hypertrophy, hyperplasia via TPM1 and TPM4, and contractility
ORM1-like 3 (ORMDL3) has strong genetic linkage to childhood onset asthma.To determine whether ORMDL3 selective expression in airway smooth muscle (ASM) influences ASM function, we used read more Cre-loxP techniques to generate transgenic mice (hORMDL3Myh11eGFP-cre), which express human ORMDL3 selectively in smooth muscle cells.In vitro studies of